The IFD5XX/4XX can interface with a host of other avionics equipment. The following list represents proven interfaces. There may be other devices that can be configured the same as one on the below list but Avidyne has not tested it and can therefore not make any compatibility claims.
| Category | Vendor | Model |
| Air Data | B&D | 2600 ADC |
| B&D | 2601 ADC | |
| B&D | 2800 ADC | |
| B&D | 900004-003 ADC | |
| Bendix King | KAD 280/480 ADC (KDC 281, 481) | |
| Shadin | 8800T Alt Computer | |
| Shadin | 9000T Alt Computer | |
| Shadin | 9200T Alt Computer | |
| Shadin | 9628XX-X Fuel/Air Data Computer | |
| Insight | TAS 1000 ADC | |
| Icarus | Instrument 3000 | |
| Sandia | SAC7-35 | |
| Garmin | GDC74A | |
| Encoding Altimeter or Blind Encoders | Bendix King | KEA-130A |
| Bendix King | KEA-346 | |
| Terra | AT-3000 | |
| Sandia | SAE5-35 | |
| Trans-Cal Industries | IA-RS232-X | |
| Trans-Cal Industries | SSD120 | |
| ACK Technologies | A-30 | |
| EADI | Honeywell | ED-600 |
| EFIS | Bendix King | EFS 40/50 |
| Avidyne | EXP5000 | |
| Aspen | Pilot PFD (EFD1000) | |
| Collins | Proline 21 | |
| Collins | EFIS 84 | |
| Honeywell | EDZ-605 | |
| Honeywell | Primus 1000 | |
| Sextant | SMD 45 | |
| Garmin | G500/600/TXi | |
| Garmin | G5 | |
| Displays | Garmin | MX20 |
| Garmin | GMX200 | |
| Garmin | GPSMAP 195 | |
| Garmin | GPSMAP 295 | |
| Garmin | GPS III Pilot | |
| Garmin | GPSMAP 196 | |
| Garmin | GPSMAP 296 | |
| Garmin | GPSMAP 396 | |
| Garmin | GPSMAP 496 | |
| Garmin | GPSMAP 695 | |
| Garmin | GPSMAP 696 | |
| Garmin | Aera 796/795 | |
| Argus | 3000 | |
| Argus | 5000 | |
| Argus | 7000 | |
| Horizon | DDMP | |
| Avidyne | EX500 | |
| Avidyne | EX600 | |
| Avidyne | EX5000 | |
| Avidyne | FlightMax Series | |
| Heading | Bendix King | KAH 460 Inertial System (KAU 461 also) |
| Collins | AHC 85 Inertial System Laseref | |
| Honeywell | HG 1075AB, HG 1095AG Inertial Systems | |
| Litef | LTR 81 Inertial System | |
| Litton | LTN 90-100 Inertial System | |
| Litton | LTN 91 Inertial System | |
| Litton | LTN 92 Inertial System | |
| EHSI | Sandel | SN3308 |
| Sandel | SN3500 | |
| Honeywell | ED-600 | |
| Fuel | Shadin | 91053XP and 91053XT-D “Digiflo-L” Digital Fuel Mgmt Systems |
| Shadin | 91204XT(38)D and 91204XT-D “Miniflo-L” Digital Fuel Mgmt Systems | |
| Shadin | 91802-() “DigiData” Fuel/Airdata | |
| JPI | EDM-700 Engine Monitor | |
| JPI | EDM-760 Engine Monitor | |
| JPI | FS-450 | |
| ARNAV | FC-10 | |
| ARNAV | FT-10 | |
| EI | FP-5L | |
| EI | CGR-30P | |
| Insight | GEM 3 | |
| Traffic | L3 | SKY497 SkyWatch |
| L3 | SKY899 SkyWatchHP | |
| Bendix King | KTA-870 | |
| Bendix King | KTA-970 | |
| Bendix King | KMH980 | |
| Bendix King | KMH880 | |
| Garmin | GTS800/820/850 | |
| Ryan | TCAD 9900B | |
| Ryan | TCAD 9900BX | |
| Avidyne | TAS-6XXA series | |
| Transponder | Garmin | GTX330 (transponder functionality only) |
| Garmin | GTX330 ES * | |
| Garmin | GTX 330D ES * | |
| Garmin | GTX335 * | |
| Garmin | GTX 345 * | |
| Garmin | GTX 327 | |
| Garmin | GTX3000 | |
| Honeywell Bendix/King | KT74 | |
| Honeywell Bendix/King | MST70B | |
| ACSS | NXT-700 | |
| L-3 | NGT9000 Series | |
| Trig | TT31/22 | |
| Rockwell Collins | TDR94/TDR94D | |
| Avidyne | AXP340/322 | |
| Bendix King | KXP80 | |
| Becker | BXT65XX | |
| Lightning | L3 | WX500 |
| Avidyne | TWX670 (“Native” format) | |
| Datalink | Garmin | GDL-69/69A*** |
| Avidyne | MLB700/100 | |
| WSI | AV-300/350 | |
| Heads-up Technologies | XMD076 | |
| Autopilot | Avidyne | DFC90 |
| Bendix King | KFC400 | |
| Bendix King | KCP320 | |
| Bendix King | KFC325 | |
| Bendix King | KFC300 | |
| Bendix King | KFC225 | |
| Bendix King | KFC200 | |
| Bendix King | KFC250 | |
| Bendix King | KFC275 | |
| Bendix King | KFC150 | |
| Bendix King | KAP150 | |
| Bendix King | KAP140 | |
| Bendix King | KAP100 | |
| Century | I | |
| Century | II | |
| Century | III | |
| Century | IV | |
| Century | 21 | |
| Century | 31/41 | |
| Century | 2000 | |
| Century | Triden | |
| Century | AK 1081 GPSS Converter | |
| Collins | APC-65 Series | |
| Collins | FGC-65 | |
| Collins | FYD-65 | |
| STec | 20 | |
| STec | 30 | |
| STec | 40 | |
| STec | 50 | |
| STec | 55 | |
| STec | 55X | |
| STec | 60 PSS | |
| STec | 60-1 | |
| STec | 60-2 | |
| STec | 65 | |
| STec | ST901 GPSS Converter | |
| Miscellaneous | Garmin | GAD42 Interface Adapter |
| EGPWS | Bendix King | MK V, MK VII, MKV-A, MK VI, MK VIII, MK XXII, MK XXI, KGP560, KGP860 |
| DME | Bendix King | KN 61 |
| Bendix King | KN 62/62A | |
| Bendix King | KN 63 | |
| Bendix King | KN 64 | |
| Bendix King | KN65 | |
| Bendix King | KDI 572 | |
| Bendix King | KDI 574 | |
| Bendix King | KDM706 | |
| Collins | DME 40 | |
| Collins | DME 42 | |
| Collins | TCR 451 | |
| Narco | DME 890 | |
| Narco | IDME 891 | |
| ARC (Cessna) | RTA-476A | |
| Nav Indicator | Garmin | GI 102/A |
| Garmin | GI 106/A | |
| Bendix King | KI 202 | |
| Bendix King | KI 203 | |
| Bendix King | KI 204 | |
| Bendix King | KI 206 | |
| Bendix King | KI 208 | |
| Bendix King | KI 208A | |
| Bendix King | KI 209 | |
| Bendix King | KI 209A | |
| Bendix King | KI 525A | |
| Bendix King | KPI 552/B | |
| Bendix King | KPI 553/A/B | |
| Century | NSD 360A | |
| Century | NSD 1000 | |
| Collins | 331A-6P | |
| Collins | 331A-9G | |
| Collins | PN-101 | |
| Mid Continent | MD 222-402/-406 | |
| Mid Continent | MD 200-20X/-30X | |
| STec | ST 180 | |
| Sperry | RD444 | |
| Sperry | RD 550A | |
| Sperry | RD 650 | |
| RMI | Bendix King | KI 229 |
| Bendix King | KNI 582 | |
| Bendix King | KDA 692 | |
| External GPS Annunciator | Mid Continent | MD41-Series |
| Staco Switch | 992561 | |
| Vivisun | 95-40-( ) | |
| Vivisun | 95-45-( ) | |
| Remote TAWS Annunciator | Garmin | 013-0079-XX |
| Mid Continent | MD41-10XX | |
| Audio Panel | Avidyne | AMX240 |
| Apollo (Garmin) | SL10 | |
| Apollo (Garmin) | SL15 | |
| Garmin | GMA 340 | |
| Garmin | GMA 347 | |
| PS Engineering | 6000 | |
| PS Engineering | 7000 | |
| PS Engineering | 8000/8000BT | |
| Bendix King | KMA 24/24H | |
| Bendix King | KMA 26 | |
| Bendix King | KMA 28 | |
| 406 ELT | Artex | ME406 |
| Ameri-King | AD 451-() | |
| Ack | E-04 | |
| Narco | Not specified | |
| Pointer | 3000 | |
| Kannad | Not specified | |
| Radar | Bendix King | RDR 2000 * |
| Bendix/King | RDR 2100 **** RDR2060 **** | |
| Bendix/King | RDS-8X **** | |
| UAT | Avidyne | Skytrax100 (formerly MLB100) |
| Avidyne | SkyTrax100B* / SkyTrax200 | |
| Freeflight Systems | FDL-978-RX** | |
| Garmin | GDL 88** |
*IFD Software version 10.2 or higher
**IFD Software version 10.2.1 or higher
*** Compatibility with P/N 011-00986-00 or 011-00987-00 only pre software 10.2.3.1. With software 10.2.3.1 or higher P/N 011-03177-X0 will function
**** IFD Software version 10.2.4.1 or higher